Developing countries face numerous barriers to conducting effective and efficient ethics reviews of international collaborative research. In addition to potentially overlooking important scientific and ethical considerations, inadequate or insufficiently trained ethics committees may insist on unwarranted changes to protocols that can impair a study's scientific or ethical validity. Moreover, poorly functioning review systems can impose substantial delays on the commencement of research, which needlessly undermine the development of new interventions for urgent medical needs. In response to these concerns, the Drugs (...) for Neglected Diseases Initiative, an independent nonprofit organization founded by a coalition of public sector and international organizations, developed a mechanism to facilitate more effective and efficient host country ethics review for a study of the use of fexinidazole for the treatment of late stage African Trypanosomiasis. The project involved the implementation of a novel ‘pre-review’ process of ethical oversight, conducted by an ad hoc committee of ethics committee representatives from African and European countries, in collaboration with internationally recognized scientific experts. This article examines the process and outcomes of this collaborative process. (shrink)

Phonological Knowledge addresses central questions in the foundations of phonology and locates them within their larger linguistic and philosophical context. Phonology is a discipline grounded in observable facts, but like any discipline it rests on conceptual assumptions. This book investigates the nature, status, and acquisition of phonological knowledge: it enquires into the conceptual and empirical foundations of phonology, and considers the relation of phonology to the theory of language and other capacities of mind. The authors address a wide range of (...) interrelated questions, the most central of which is this: is phonological knowledge different from linguistic knowledge in general? They offer responses to this question from a variety of perspectives, each of which has consequences for how phonology and language are conceived. Each also involves a host of further questions concerning the modularity of mind and of language; whether phonology should be included in the language faculty; the nature-convention debate; the content of phonological elements and its relation to phonetic substance; the implications of sign languages for phonology; whether functional and variationist considerations are relevant in phonology; how phonological knowledge arises; and, not least, the data and methods appropriate for phonological inquiry. Phonological Knowledge is an important contribution to the most fundamental issues in phonology and the understanding of language. It will interest researchers in and advanced students of phonology, linguistic theory, and philosophy of language.In addition to the editors, the authors are Mary Beckman, Silvain Bromberger, Jennifer Fitzpatrick, Paul Foulkes, Mark Hale, Morris Hallé, John Harris, Harry van der Hulst, Robert Ladd, G. Lindsey, Scott Myers, Janet Pierrehumbert, Charles Reiss, Shelley Velleman, Marilyn Vihman, and Linda Wheeldon.By relating foundational questions of phonology to their larger linguistic, cognitive, and philosophical contexts this book will generate interest not only among phonologists and their advanced students, but also among all those concerned to understand the forms and functions of language. (shrink)

This essay, by the editor of Common Knowledge, introduces the sixth and final installment of “Fuzzy Studies,” the journal's “Symposium on the Consequence of Blur.” Suggesting that “Fuzzy Studies” should be understood in the context of a desultory campaign against zeal conducted in the journal for almost twenty years, he explains that the editors' assumption has been that any authentic case for the less adamant modes of thinking, or the less focused ways of seeing, needs to be unenthusiastic and carefully (...) ramified. To establish the distinction between overenthused and unemphatic approaches to blur, he contrasts the ecstatically amorphous “Blur building” with examples of classical Chinese landscape painting. Elizabeth Diller and Richard Scofidio, in their book blur: the making of nothing, chronicle the development of their plans for the Blur building and, in the process, inadvertently show that, to overbear various negative associations of blur and fog, the authors/architects grew self-contradictorily emphatic about the need to produce de-emphasis in architecture and in modern life. Perl shows how this self-contradiction appears also in phenomenology-inflected writings on blur by T. J. Clark, Yve-Alain Bois and Rosalind Kraus, J.-P. Sartre, and Georges Bataille, but not in the work of the phenomenologist François Jullien, whose book The Great Image Has No Form analyzes the role of blur in classical Chinese art theory and practice. Where traditional Western painting, Jullien argues, calls for voyeuristically intense focus, traditional Chinese painting stimulates “dé-tente, relaxation or ‘untensing’.” Intense focus on a blur is still, Perl observes, an intense focus. In describing a painting by the Yuan Dynasty master Ni Zan, Perl concludes that the only way to be un-self-contradictorily positive about fuzziness, whether in logic or aesthetics, is to de-reify and de-differentiate with the aim of achieving blandness. (shrink)

We present a comprehensive model that integrates virtues, values, character strengths and ethical decision making (EDM). We describe how a largely consequentialist ethical framework has dominated most EDM scholarship to date. We suggest that reintroducing a virtue ethical perspective to existing EDM theories can help to illustrate deficiencies in existing decision-making models, and suggest that character strengths and motivational values can serve as natural bridges that link a virtue framework to EDM in organizations. In conjunction with the more fully formulated (...) extant research on situational determinants, we present and discuss our model that introduces a virtue based orientation to EDM. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:La séduction de la fiction by Jean-François VernayDiana MistreanuVernay, Jean-François. La séduction de la fiction. Hermann, 2019. 214pp.Published in Hermann’s prestigious “Savoirs Lettres” book series founded by Michel Foucault, Jean-François Vernay’s latest work is a compelling neurophenomenology of literary fiction. This makes it a valuable contribution to the burgeoning field of cognitive literary studies pioneered in Anglo-Saxon research in the late 1970s, but which French academia, with a (...) few notable exceptions such as Jean-Marie Schaeffer, Pierre-Louis Patoine, Alexandre Gefen, Catherine Grall, or Françoise Lavocat, is still largely reluctant to embrace. The author is a lecturer in Australian studies at the Global Institute in Sydney, and he is a bilingual literary scholar whose recent research explores the complex interface between fiction and human cognition.Vernay’s book starts by restating a narratological cliché: in the words of Paul Valéry, stories accompany humans from the cradle to the tomb, as monsters, pirates, fairies, and other fantastic creatures fascinate children’s minds from the first years of their lives (7). A truism follows this cliché: the origin of any story is the human brain (16), as the author reminds us by underlining the bio-anthropological origins of fiction in pages that cite the works of Umberto Eco and Nancy Huston (the writer who coined the notion of “espèce fabulatrice,” “the tale-teller species” [2008]), and that echo the research of scholars such as Mark Turner (1996) and Jean-Marie Schaeffer (1999). Indeed, oral and written stories are not only created, but also interpreted by human minds, triggering states and emotions that range from extreme boredom to excitement and inviting identification with fictional characters. Nevertheless, the mechanisms of the interaction between the human mind and brain and one of its most sophisticated products, namely fiction, are largely still understudied in the field of literature. Placing fiction under the sign of seduction (8) – which allows us to read between the lines an homage to Roland Barthes, the theorist of the “plaisir du texte” referenced later in the book (85-86) – Vernay defines works of fiction as catalysts of a sensori-affective experience [End Page 151] that engages almost all our senses and arouses emotions (“le vecteur d’une expérience sensori-affective qui sollicite la quasi-totalité de nos sens et suscite des émois” [19]). Characterized by the interdisciplinarity that forms the core of cognitive approaches to fiction, Vernay’s study investigates the literary phenomenon in its complexity, asking not only how fiction seduces us, but also why it sometimes fails to do so. Drawing on state-of-the-art research in cognitive psychology and neuroscience, the book manages to eschew over-simplified or reductionist analyses. Our engagement with and consumption of literary fiction is thus analyzed by discussing marketing strategies and editorial choices, the activity of reading as a solitary pleasure versus a professional obligation, as well as the interplay between society, politics, and educational curricula. The author answers his multi-layered research question in nine different chapters, each of them exploring one facet of the relationship between literature and the human mind.The first chapter, “Émois livresques,” highlights the marketing value of books, as well as their status as objects of consumption, in the capitalistic sense of the word. Books are presented here as the targets of our desire, since in financial terms, the notion of reader, the author reminds us, is a mere euphemism for that of consumer (20-22). As we are entering the era of what Yves Citton, often quoted in this essay, calls “cognitive capitalism,” a system in which society is conceptualized as a set of machines that process information (21), fictional literature, along with the arts, is devalued. To counterbalance this trend, Vernay explains, the book industry has to adopt effective strategies that create a desire for consumption. Thus, this chapter addresses the editorial and marketing techniques designed to attract our attention and trigger our impulse to buy and read. From the smell and color of books to the blurb and the careful mention of literary prizes, no detail is overlooked or considered redundant.After addressing the... (shrink)

Different sort of people are interested in personal identity. Philosophers frequently ask what it takes to remain oneself. Caregivers imagine their patients’ experience. But both philosophers and caregivers think from the armchair: they can only make assumptions about what it would be like to wake up with massive bodily changes. Patients with a locked-in syndrome suffer a full body paralysis without cognitive impairment. They can tell us what it is like. Forty-four chronic LIS patients and 20 age-matched healthy medical professionals (...) answered a 15-items questionnaire targeting: global evaluation of identity, body representation and experienced meaning in life. In patients, self-reported identity was correlated with B and C. Patients differed with controls in C. These results suggest that the paralyzed body remains a strong component of patients’ experienced identity, that patients can adjust to objectives changes perceived as meaningful and that caregivers fail in predicting patients’ experience. (shrink)

Il s?agit de nuancer l?opposition massive, mise en place par Michel Foucault dans sa préface à la traduction anglaise du Normal et le patho­logique , entre la tradition phénoménologique et l?épistémologie française. Cette opposition est raffinée sur la base d?une confrontation entre la pensée de Georges Canguilhem et celle du psychiatre allemand Erwin Straus, qui tâche, dans son ouvrage majeur Vom Sinn der Sinne , de poser les fondements d?une psychologie phénoménologique. La confrontation s?organise autour de deux thématiques abordées de (...) manière centrale par les deux auteurs, l?une portant sur la physiologie, le problème du réflexe et les rapports entre le vivant et son milieu, l?autre sur les notions de normal et de pathologique. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS Because we are critical realists, we must take this perspective on the world afforded by physics and cosmology seriously but not too literally. This means that in thinking how it might influence our models of God's relation to and actions in the world, it is only the broadest, general features, and these the most soundly established, that we must reckon with (60). 199 The trouble is, of (...) course, that in the version of critical realism developed in the first lecture, more confident of the reality of theoretical entities than of the truth of statements about them, it is just the most general theoretical features that we are least entitled to regard as " soundly established." Perhaps I have misunderstood Peacocke's version of critical realism; but, if so, it gets much less support from philosophers like Hacking and McMullin than he supposes. That the big picture is (probably close to) right, though the details might be wrong, is not what the realists among contemporary philosophers of science typically contendmore nearly the opposite. University of Houston Houston, Texas WILLIAM H. AUSTIN The Letters and Diaries of John Henry Newman, Vol. VI. Edited by GERARD TR.ACEY. New York: The Clarendon Press, Oxford University Press, 1984. Pp. 417. $49. 95. A Packet of Letters: A Selection from the Correspondence of John Henry Newman. Edited by JOYCE SUGG. New York: The Clarendon Press, Oxford University Press, 1983. Pp. 230. $19.95. Volume Six of Newman's letters and diaries documents the years 1837 and 1838 which, though far from the most eventful years of Newman's life, saw the culmination of a remarkable development of his influence, an influence which at the same time was warmly welcomed by some and stridently criticized by others. A visitor to Oxford in November of 1837 gave the following picture of Newman's position: It was allowed that the Doctor [Pusey] and Newman governed the University, and that nothing could withstand the influence of themselves and their friends. Every man of talent who during the last six years has come to Oxford has joined Newman, and when he preaches at St. Mary's (on every Sunday afternoon) all the men of talent in the University come to hear him, although at the loss of their dinner. His triumph over the mental empire of Oxford was said to be complete! (164) 200 llOOK' REVIEWS Newman no doubt would have explained that " triumph " in the same way he described a putative disciple of Pusey's-" he is Pusey's, only so far as Pusey is Truth's..." (175). But though he was an unwilling leader, he was a leader nevertheless. His influence, however, brought as much criticism as accolade; even Pusey felt sorry for the responsibility attributed to Newman, writing to Keble that" it is not fair to let Newman bear the whole brunt alone, as if his Theology were something peculiar, or ~they call it, the Newmania" (51, note 2). Pusey's sympathy was expressed in March of 1837; in November of 1838 we see Newman's own assessment-as if too exhausted to. hide his exasperation any longer, he wrote to Keble: I wish parties would seriously ask themselves what they desire of me.... People really should put themselves into my place, and consider how the appearance of suspicion, jealousy, and discontent is likely to affect one, who is most conscious that every thing he does is imperfect, and therefore soon begins so to suspect every thing that he does as to have no heart and little power remaining to do any thing at all. (347) He suffered under the general criticism that he was "betraying a cause and unsettling people " (307), and, even when he could recognize good as coming from his work, the benefit was an inferred, not a felt, one-he likened himself to " the pane of glass... which transmits heat yet is cold " (57). These letters show us a man who never found writing easy (192-3), yet wrote prolifically nonetheless; the year 1837 in particular was filled with such commitments. The Lectures on the Prophetical Office of the Church, viewed relatively to Romanism and Popular Protestantism (his attempt at a... (shrink)

La pensée derridienne a laissé sur le paysage intellectuel contemporain une trace aussi profonde que difficile à interpréter. De nombreux travaux paraissent s’en inspirer dans divers champs, des sciences humaines à l’architecture en passant par le droit et la théologie. Et pourtant, alors même que son influence semble indéniable, sa signification demeure incertaine, de sorte que l’on peut légitimement...

Nanomaterials have attracted much interest in the medical field and related applications as their distinct properties in the nanorange enable new and improved diagnosis and therapies. Owing to these properties and their potential interactions with the human body and the environment, the impact of nanomaterials on humans and their potential toxicity have been regarded a very significant issue. Consequently, nanomaterials are the subject of a wide range of cutting-edge research efforts in the medical and related fields to thoroughly probe their (...) potential beneficial utilizations and their more negative effects. We posit that the lack of standardization in the field is a serious shortcoming as it has led to the establishment of methods and results that do not ensure sufficient consistency and thus in our view can possibly result in research outputs that are not as robust as they should be. The main aim of this article is to present how NanoDiaRA, a large FP7 European multidisciplinary project that seeks to investigate and develop nanotechnology-based diagnostic systems, has developed and implemented robust, standardized methods to support research practices involving the engineering and manipulation of nanomaterials. First, to contextualize this research, an overview of the measures defined by different regulatory bodies concerning nanosafety is presented. Although these authorities have been very active in the past several years, many questions remain unanswered in our view. Second, a number of national and international projects that attempted to ensure more reliable exchanges of methods and results are discussed. However, the frequent lack of publication of procedures and protocols in research can often be a hindrance for sharing those good practices. Subsequently, the efforts made through NanoDiaRA to introduce standardized methods and techniques to support the development and utilization of nanomaterials are discussed in depth. A series of semi-structured interviews were conducted with the partners of this project, and the interviews were analyzed thematically to highlight the determined efforts of the researchers to standardize their methods. Finally, some recommendations are made toward the setting up of well-defined methods to support the high-quality work of collaborative nanoparticle-based research and development projects and to enhance standardization processes. (shrink)

Ce texte se présente d’abord comme une description de deux portraits de Michel Leiris par le peintre Francis Bacon. Mais il s’agit en même temps d’une méditation sur la ressemblance figurative. Que peut signifier le portrait d’un écrivain qui lui-même n’a pas cessé de se figurer dans son œuvre écrite?

Balancing Change and Tradition in Global Education Reform is an invaluable resource for policymakers, faculty, students, and anyone interested in how decisions made about the education system ultimately affect the quality of education, educational access, and social justice.

Patrick Turmel,François Boucher,Marie-Noëlle Carré.

Cet article vise à exposer et à examiner la conception de la vérité chez Derrida. Pour ce faire, nous proposerons une rapide définition de la déconstruction dans son ensemble (I). Cette présentation permettra de comprendre, d’une part, la critique derridienne de la vérité comme logos (c’est-à-dire comme une pièce essentielle de la « métaphysique ») (II), mais aussi, d’autre part, l’approche plus positive dont ce concept fait progressivement l’objet, aboutissant à l’idée d’une vérité performative et pragmatique, liée notamment au concept (...) de témoignage (III). Enfin, nous essaierons de montrer que le problème de la vérité révèle une tension entre deux strates de discours qui divisent la déconstruction dans son ensemble, et dont on peut interroger l’homogénéité (IV). (shrink)

Previous studies using the dot-perspective task postulated that people automatically take into account others' perspective even when it prevents them from achieving their own goals. This human ability may be of key importance for the ascription of mental states and social interactions. The cognitive and emotional determinants of automatic perspective taking is still matter of debate. To address this issue, we examined the performance in the Samson et al. APT task in 91 healthy adults who underwent a detailed neuropsychological testing (...) including assessment of their general intelligence, attention and impulsivity, alexithymia, and measures of affective empathy and explicit theory of mind. Univariate and multiple linear regression models were used to explore the association between mean reaction times in the APT task, and the CPT-II parameters, WAIS global score, TAS, and GeSoCS and mini-SEA scores. Only the CPT-II parameters were significantly associated with the mean reaction times. Increased omissions, commissions, and detectability as well as hit reaction time standard error in CPT-II were all related to worse performances both in Self and Other conditions. The mean number of errors was negatively associated with the GeSoCS score. Among the variables studied, only CPT-II parameters had a significant impact on egocentric and altercentric interference. Neither global intelligence nor alexithymia have an effect on dot-perspective task performance. The present findings suggest that people with lower attentional resources and increased impulsivity display worse performances in the APT task and are less responsive to both egocentric and altercentric interference. (shrink)

In the context of long waiting time to access rehabilitation services, a large majority of settings use referral prioritization to help manage waiting lists. Prioritization practices vary greatly between settings and there is little consensus on how best to prioritize referrals. This paper describes the prioritization processes for physiotherapy services in Québec and its potential implications in terms of equity in access to services. This is a secondary analysis of a survey of outpatient physiotherapy departments (n=98; proportion of participation was (...) 99%) conducted in 2015 across publicly funded hospitals in Québec. In many settings, persons with acute orthopaedic conditions were prioritized while chronic conditions were given a lower priority. There were 72 different combinations of prioritization criteria used in outpatient physiotherapy departments. Variability was also observed in the type of personnel involved in the prioritization process, the number of priority levels used to rank the referrals and the source of information used to prioritize referrals. These results highlight potential issues regarding equity in access to physiotherapy services: the prioritization of persons with acute conditions to the detriment of those with chronic conditions, the lack of consensus on a fair prioritization process and the importance to adequately assess patients’ needs for treatment. Further research and interventions on prioritization criteria and processes are needed to ensure equitable access to physiotherapy services, especially in the public sector. (shrink)

In the context of long waiting time to access rehabilitation services, a large majority of settings use referral prioritization to help manage waiting lists. Prioritization practices vary greatly between settings and there is little consensus on how best to prioritize referrals. This paper describes the prioritization processes for physiotherapy services in Québec and its potential implications in terms of equity in access to services. This is a secondary analysis of a survey of outpatient physiotherapy departments conducted in 2015 across publicly (...) funded hospitals in Québec. In many settings, persons with acute orthopaedic conditions were prioritized while chronic conditions were given a lower priority. There were 72 different combinations of prioritization criteria used in outpatient physiotherapy departments. Variability was also observed in the type of personnel involved in the prioritization process, the number of priority levels used to rank the referrals and the source of information used to prioritize referrals. These results highlight potential issues regarding equity in access to physiotherapy services: the prioritization of persons with acute conditions to the detriment of those with chronic conditions, the lack of consensus on a fair prioritization process and the importance to adequately assess patients’ needs for treatment. Further research and interventions on prioritization criteria and processes are needed to ensure equitable access to physiotherapy services, especially in the public sector. (shrink)

BackgroundThe advent of learning healthcare systems (LHSs) raises an important implementation challenge concerning how to request and manage consent to support secondary use of data in learning cycles, particularly research activities. Current consent models in Quebec were not established with the context of LHSs in mind and do not support the agility and transparency required to obtain consent from all involved, especially the citizens. Therefore, a new approach to consent is needed. Previous work identified the meta-consent model as a promising (...) alternative to fulfill the requirements of LHSs, particularly large-scale deployments. We elicited the public’s attitude toward the meta-consent model to evaluate if the model could be understood by the citizens and would be deemed acceptable to prepare for its possible implementation in Quebec.MethodsEight focus groups, with a total of 63 members of the general public from various backgrounds were conducted in Quebec, Canada, in 2019. Explicit attention was given to literacy levels, language spoken at home and rural vs urban settings. We assessed attitudes, concerns and facilitators regarding key components of the meta-consent model: predefined categories to personalized consent requests, a dynamic web-based infrastructure to record meta-consent, and default settings. To analyse the discussions, a thematic content analysis was performed using a qualitative software.ResultsOur findings showed that participants were supportive of this new approach of consent as it promotes transparency and offers autonomy for the management of their health data. Key facilitators were identified to be considered in the implementation of a meta-consent model in the Quebec LHSs: information and transparency, awareness campaigns, development of educational tools, collaboration of front-line healthcare professionals, default settings deemed acceptable by the society as well as close partnerships with recognized and trusted institutions.ConclusionsThis qualitative study reveals the openness of a sample of the Quebec population regarding the meta-consent model for secondary use of health data for research. This first exploratory study conducted with the public is an important step in guiding decision-makers in the next phases of implementing the various strategies to support access and use of health data in Quebec. (shrink)

Voltaire’s classic novel Candide relates the misadventures of a young optimist who leaves his sheltered childhood to find his way in a cruel and irrational world. Fast-paced and full of dark humor, the novel mocks the suggestion that “all is well” and challenges us to create a better world. This Broadview Edition follows the text of a 1759 English translation that was released concurrently with Voltaire's first French edition. Candide is supplemented by Voltaire's most important poetic and humanistic writings on (...) God and evil, the Poem upon the Destruction of Lisbon and We Must Take Sides. The editor's introduction situates the novel in its philosophical and intellectual setting; the appendices include other writings by Voltaire, as well as related writings by Bayle, Leibniz, Pope, Rousseau, and others that place the work in its poetic, philosophical, and humanistic contexts. (shrink)